シラバス情報

教員名 ： 定家　真人
科目授業名称（和文）　Name of the subject/class (in Japanese)
生物科学大学院特論１
科目授業名称（英文）　Name of the subject/class (in English)
Current Topics in Advanced Bioscience 1
授業コード　Class code
996E513
科目番号　Course number
64GRRES605

教員名
Louis John Irving、竹岡　彩、織田　政紀、James Alan Hejna、市川　寛子、朽津　和幸、倉持　幸司、西浜　竜一、和田　直之、中島　将博、中村　由和、萩原　明、古屋　俊樹、前澤　創、政池　知子、荒添　貴之、鈴木　智順、定家　真人
Instructor
Mahito Sadaie, Louis John Irving, Aya Takeoka, Masaki Orita, James Alan Hejna, Hiroko Ichikawa, Kazuyuki Kuchitsu, Kouji Kuramochi, Ryuichi Nishihama, Naoyuki Wada, Masahiro Nakajima, Yoshikazu Nakamura, Akari Hagiwara, Toshiki Furuya, So Maezawa, Tomoko Masaike, Takayuki Arazoe, Tomonori Suzuki

開講年度学期
2026年度後期
Year
2026年度
Semester
②Second semester
曜日時限
集中講義
Class hours
Intensive Course (Classes will generally be held during the 3rd–5th periods on Mondays｜授業は原則的に​授業期間中の月曜日の3時限目から5時限目に行われます｜Classes may be scheduled on Saturdays if necessary due to scheduling constraints｜日程調整が困難な場合は土曜日に行われる可能性もあります)

開講学科・専攻　Department
創域理工学研究科　生命生物科学専攻

Department of Applied Biological Science, Graduate School of Science and Technology
単位数　Course credit
2.0単位
授業の方法　Teaching method
講義

Lecture
外国語のみの科目（使用言語）　Course in only foreign languages (languages)
英語　English
授業の主な実施形態　Main class format
① [対面]対面授業/ [On-site] On-site class

概要　Description
本科目は、履修者が現在育成中の実力や人間力を今後幅広く活かすための強力なツールとして英語に重点を置き、参加者同士が協力し合うことで、英語を積極的に使う姿勢を引き出そうとするものである。
This course emphasizes English as a powerful tool for making use of the abilities and personal qualities students are currently developing and encourages the active use of English through cooperation among participants.
目的　Objectives
生物科学や生命科学を英語で理解し表現できる人材を育成する。
This course aims to develop students' ability to understand and communicate concepts in the biological and life sciences in English.
到達目標　Outcomes
英語を読む・書くこと、また英語で話す・会話することに対する消極性の壁を低減することができる。
Students will be able to overcome their reluctance to read and write in English and to speak and engage in conversation in English.
卒業認定・学位授与の方針との関係（学部科目のみ）
履修上の注意　Course notes prerequisites
-
アクティブ・ラーニング科目　Teaching type（Active Learning）
課題に対する作文　Essay／小テストの実施　Quiz type test／ディベート・ディスカッション　Debate/Discussion／グループワーク　Group work／プレゼンテーション　Presentation
-

準備学習・復習　Preparation and review
オムニバス形式の授業なので、授業内容のそれぞれの分野の現状と発展についての、予習、復習が必要。
Because this course consists of lectures by different instructors, studends are expected to prepare for and review the current status and recent developments in each field covered in the course.
成績評価方法　Performance grading policy
各講師ごとに試験やレポートを課し、これに受講態度を加味して総合的に評価する。
Each instructor will assign an exam or a report, and the final grade will be determined based on these assessments together with students’ class participation.
学修成果の評価　Evaluation of academic achievement
・S：到達目標を十分に達成し、極めて優秀な成果を収めている
・A：到達目標を十分に達成している
・B：到達目標を達成している
・C：到達目標を最低限達成している
・D：到達目標を達成していない
・-：学修成果の評価を判断する要件を欠格している

・S：Achieved outcomes, excellent result
・A：Achieved outcomes, good result
・B：Achieved outcomes
・C：Minimally achieved outcomes
・D：Did not achieve outcomes
・-：Failed to meet even the minimal requirements for evaluation

教科書　Textbooks/Readings
教科書の使用有無（有=Y , 無=N）　Textbook used(Y for yes, N for no)
N
書誌情報　Bibliographic information
-
MyKiTSのURL（教科書販売サイト）　URL for MyKiTS(textbook sales site)
教科書および一部の参考書は、MyKiTS (教科書販売サイト) から検索・購入可能です。
​https://gomykits.kinokuniya.co.jp/tokyorika/​​​

It is possible to search for and purchase textbooks and certain reference materials at MyKiTS (online textbook store).
​​https://gomykits.kinokuniya.co.jp/tokyorika/

参考書・その他資料　Reference and other materials
必要に応じて授業中に資料を配布する。

Handouts will be distributed in class as necessary.



授業計画　Class plan
  • すべての授業を対面で受講することを求める。
  • 開講順序・内容は変更の可能性がある（変更がある場合は講義中やLETUS等で発表する）
  • 授業は原則的に授業期間中の月曜日の3時限目から5時限目に行われます（日程調整が困難な場合は土曜日に行われる可能性もあります）。
  • Students are required to attend all classes in person.
  • The order and content of the lectures may be subject to change. Any changes will be announced during class or via LETUS.
  • Classes will generally be held during the 3rd–5th periods on Mondays. Classes may be scheduled on Saturdays if necessary due to scheduling constraints.
  • 2026/4/16現在、以下の日時に行う予定となっています。変更の可能性もあるので、LETUSのお知らせをチェックしてください。
    • Hejna先生は9/14の3–5限
    • 竹岡先生は10/19の3–5限
    • 織田先生は11/9の14:40以降の時間の中の90分間
    • 朽津先生は11/16の5限
    • Irving先生は12/7と12/14の15:30–17:50

【１】DNA structure and vulnerability to clastogens and mutagens (Hejna)
  • Structure of DNA, exposed residues, and types of DNA damage
  • Cellular responses to DNA damage (repair vs. tolerance)
  • Relation of DNA damage to cell cycle, tumor suppressors, and checkpoints
【２】DNA Repair Pathways (Hejna)
  • Damage reversal and prevention (including piRNAs)
  • Base Excision Repair (BER)
  • Nucleotide Excision Repair (NER)
  • Transcription-Coupled Repair (TCR)
  • Single-strand Break (SSB) and Double-strand-Break (DSB) repair
  • DNA Interstrand Crosslink (ICL) Repair
  • Bypass polymerases
  • Primpol
  • programmed DSBs: adaptive immunity and meiosis
【３】Human genetic diseases and DNA repair (Hejna)
  • Cancer, DNA repair and tumor suppressors
  • Targeting DNA repair pathways for cancer treatment
  • Other topics
DNA repair in Plants
Extremophiles-Deinococcus radiodurans, tardigrades;
Peto’s paradox
【４】【５】【６】Plant Ecophysiology (Irving)
Plants have evolved a wide variety of mechanisms to deal with nutrient limitation.  These can range from changes in their physiology and biochemistry, to strategies where they acquire nutrients from symbiotic partners, steal them from a host plant, or trap and digest prey.  These lectures will explore each of these strategies and how the relate to environmental conditions.  
【４】Dealing with limiting resources; physiological adaptation and symbioses (Irving)
  • Learning outcomes
After this class, students will understand: 1) the main ways a plant can adapt to nutrient deficiency; 2) how symbionts can aid in resource acquisition
  • Topics covered
Nutrients are patchily distributed
Changes in root physiology (root hairs, etc)
Root growth strategies (competition for nutrients)
N fixation with rhizobia
Mycorrhizae
  • How are these outcomes evaluated?Homework
Q1; why do plants engage in root proliferation in nutrient patches?
Q2; Outline the costs and benefits of symbioses for host plants
【５】Dealing with limiting resources: Parasitism (Irving)
  • Learning outcomes
After this class, students will understand: 1) why some plants steal resources from others; 2) the role of host recognition in the host – parasite relationship
  • Topics covered
What are parasitic plants?  Economic damage
Parasitism is associated with resource limited environments
Hemiparasites & Holoparasites; root and shoot parasites
Host recognition – strigolactones, HIFs
How much do parasites steal?
  • How are these outcomes evaluated?
Homework
Q1; outline the key differences between holoparasites and hemiparasites
Q2; How do we quantify the proportion of host-derived C in Striga?
【６】Dealing with limiting resources: Carnivory (Irving)
  • Learning outcomes
After this class, students will understand: 1) the environmental drivers of plant carnivory; 2) the importance of prey nutrients in the plant nutrient budget
  • Topics covered
Carnivorous plants live in nutrient-poor environments
What is carnivory?  How many species?  
Types of traps
Growth benefits of carnivory
Cost:benefit model of carnivory
  • How are these outcomes evaluated?
Homework
Q1; Outline three types of traps employed by carnivorous plants, and their main prey
Q2; How does the contribution of prey resources change with environmental resource availability?
【７】Introduction to Circuit and Systems-level Neuroscience (Takeoka)
  • Basics of Systems Neuroscience tools
  • Motor control and adaptation theories
【８】Motor control and learning: Spinal cord (Takeoka)
  • Proprioception and other somatosensory systems
  • Behavioral evidence of spinal cord plasticity
  • Neuronal basis of motor adaptation and learning
【９】Sensory regulation of motor output (Takeoka)
  • Visual regulation of motor output 
  • Error detection and neuronal encoding
【１０】【１１】【１２】Dermatology-Based Cosmetic Formulation Design (Orita)
This lecture explores the efficacy of cosmetic products grounded in a deep understanding of skin physiology and structure. It covers the barrier functions of the stratum corneum and moisturizing mechanisms, the physiological impact of cleansing and surfactants on the skin, and the principles of photoaging and UV protection (sunscreens). The session will examine these topics through the dual lens of dermatological evidence and advanced formulation technologies.
【１３】Dynamics of Plant Signaling: the ROS-Ca2+ Network in Adaptation, Development, and Information Processing (Kuchitsu)
We will explore the plant signaling network as a sophisticated, distributed information processing system. By integrating molecular mechanisms—specifically RBOH-mediated ROS production and ion channel-mediated Ca2+ signaling—we will examine how plants perceive, encode, and propagate environmental and developmental cues. This signaling framework provides systemic coordination that parallels the complexity of animal immune and nervous systems, yet is uniquely evolved in plants. Through the analysis of spatiotemporal signal dynamics—including rapid electrical and chemical waves—we will investigate how plants orchestrate complex survival strategies in the absence of a central brain.
【１４】【１５】Talks about your research
Students will give short oral presentations in English about their research.

担当教員の実務経験とそれを活かした教育内容　Work experience of the instructor
-
教育用ソフトウェア　Educational software
-
-

備考　Remarks

授業でのBYOD PCの利用有無　Whether or not students may use BYOD PCs in class
Y
授業での仮想PCの利用有無　Whether or not students may use a virtual PC in class
N